Gene therapy for Batten disease: A systemic review of preclinical and clinical studies [2025] - 1,796KB
by Sanjeev Kumar Jain, Bablu Kumar Gaur, Usha Kiran Pothu, Rupa Rajbhandari Singh
Background: Batten disease (BD), or neuronal ceroid lipofuscinosis (NCL), is a group of rare, fatal neurodegenerative disorders caused by mutations in CLN genes, leading to lysosomal dysfunction and p...

Prognostic marker PTPN6 in glioma and its relationship with immune infiltration [2025] - 2,035KB
by Kaiqin Chen, JianGuo, Ruicheng, He Li, Hesen Huang, Shangming Zhang
Background & Objective: Glioma is a type of malignant tumor that develops in the neurological system, and identification of glioma biomarkers is critical. PTPN6 is a protein tyrosine phosphatase. The ...

Serum chemokine profiling in spinal ependymoma: Correlation with tumor characteristics and prognostic implications [2025] - 1,333KB
by Noor Saadoon Abdulazeez Alzori, Maryam Azimzadeh, Majid Reza Farrokhi, Sina Vakili, Morteza Jafarinia
Background: Spinal ependymomas are rare neoplasms that originate from the ependymal cells lining the central canal of the spinal cord. Since serum levels of cytokines and chemokines are imbalanced in ...

The relationship between disease severity, treatment adherence, inflammation, and neurocognitive functions in patients with obstructive sleep apnea syndrome [2025] - 395KB
by Ömer Faruk ILDIZ, Ahmet Hakan EKMEKCİ, Fettah EREN, Muslu Kazım KÖREZ
Obstructive: Sleep Apnea Syndrome (OSAS) is a condition marked by recurrent interruptions in airflow during sleep, causing intermittent hypoxia and inflammation. These changes adversely affect neuroco...

PAI-1 4G/5G mutation leads to acute mountain sickness with reversible splenial lesion syndrome and intracranial arteriovenous thrombosis: A case report and literature review [2025] - 833KB
by Yi Wang, Chao Zhen, XinJuan Yu, HaiFeng Wang, DongHui Shen, YuJing Wang, Ji Wang, YaBo Wang, Xin Wang
Acute mountain sickness (AMS) rarely manifests with concurrent reversible splenial lesion syndrome (RESLES), cerebral venous sinus thrombosis (CVST), and bilateral watershed infarctions. We present th...

Reversible cerebral vasoconstriction syndrome associated with paroxysmal nocturnal hemoglobinuria: A case study [2025] - 1,726KB
by Qianqian Fan, Yongmin Chen, Dandan Jia, Zhenhua Song, Qifu Li
Reversible cerebral vasoconstriction syndrome (RCVS), characterized by thunderclap headaches (TCH) and other clinical and radiological manifestations, typically occurs under some triggering conditions...

Pancytopenia and Stevens-Johnson syndrome induced by oxcarbazepine: A case report [2025] - 564KB
by Jialei Chen, Wenguang Hu, Mingping Lan, Qun Yang
Oxcarbazepine (OXC), a commonly prescribed medication for focal and secondarily generalized seizure, has been associated with the development of pancytopenia in approximately 1% of patients. The incid...

Neurosyphilis presenting with behaviour change and temporal and frontal lobe MRI abnormalities [2025] - 847KB
by Kevin Soon Hwee Teo, Amy Aimei Jiang, Yi Man Goh, Andrew C F Hui
General paresis is the result of a chronic, slowly progressive meningoencephalitis secondary to central nervous system infection by Treponema pallidum and its onset is insidious with predominant cogni...

Neurolisteriosis mimicking Weber’s syndrome: A rare clinical presentation [2025] - 1,670KB
by Mimi Nashra Mohd Noh, Hanis Rabeah Kamaruzaman, Suk Hui Gan, Nurfarhan Lokman, Shalini Bhaskar
Neurolisteriosis, an infection of the central nervous system caused by Listeria monocytogenes, can present with a wide variety of clinical signs and symptoms thereby rendering the diagnosis and treatm...

Amiodarone-induced parkinsonism [2025] - 269KB
by Paulo Cataniag, Cid Czarina Diesta, Jed Noel Ong
Drug-induced parkinsonism (DIP) is the second most common cause of parkinsonism, primarily resulting from medications that block dopamine D2 receptors or reduce dopamine in the basal ganglia. While an...