Can epilepsy be prevented? [2011] - 227KB
by T Ono, SL Moshé
The development of epilepsy may be related to genetic and epigenetic factors often in combination with non-genetically determined structural brain abnormalities. Prevention of epileptogenesis (i.e., a...

Heredity in epilepsy – An historical overview [2011] - 182KB
by S Shorvon
This paper provides an overview of the concepts of the genetic causation of epilepsy from 1860 to the present day, and an appreciation of the impact of these concepts today. The paper is a summary of ...

Genetics of large populations in epilepsy: Association studies – Trials and tribulations [2011] - 91KB
by NCK Tan
Unlike Mendelian epilepsies, complex epilepsies may be due to the effect of several or multiple susceptibility genes. Association studies have been used in the past decade to help identify common gene...

Consanguinity and inherited epilepsies [2011] - 76KB
by S Jain
As a working definition, unions contracted between persons biologically related as second cousins or closer are categorized as consanguineous. The offspring of consanguineous relationships are at grea...

Epilepsy in head injury [2011] - 110KB
by BM Selladurai
Posttraumatic epilepsy accounts for about 20% of symptomatic epilepsy in the general population and about 5% patients referred to epilepsy centers. Mechanisms that can provoke posttraumatic seizures a...

Epilepsies due to perinatal brain injuries: Focus on prevention [2011] - 100KB
by V Udani
Epilepsy due to perinatal brain injury remains an important problem in developing countries. Brain injury can be prominent in perinatal asphyxia, neonatal hypoglycemia, sepsis- meningitis, late hemorr...

Tuberous sclerosis complex and the mTOR pathway [2011] - 175KB
by KJ Kim
Tuberous sclerosis complex (TSC) is a neurocutaneous disease characterized by the growth of hamartomas in many tissues and organs. The most prominent neurological manifestation of TSC is epileptic sei...

Basic physiology of the EEG [2011] - 124KB
by S Fried, SL Moshé
The basic physiology of the EEG and its rhythms has been the topic of intense research since its discovery in the 1920s, the subject of innumerable textbooks and articles. In this overview, we present...

Predictors of outcome in newly diagnosed epilepsy: Clinical, EEG and MRI [2011] - 88KB
by EL So
Many clinical features in epilepsy have been assessed for their association with long-term epilepsy outcome. These factors include gender, age of seizure onset, type and duration of epilepsy, IQ, neur...

Psychosocial outcomes of newly-diagnosed epilepsy [2011] - 216KB
by SJ Wilson
It is well-established that the diagnosis of a chronic or life-threatening illness typically gives rise to significant adjustment issues, as an individual seeks to make the necessary changes to lifest...