Focal EEG abnormalities in juvenile myoclonic epilepsy [2007] - 115KB
by S Sailaja, S Sita Jayalakshmi, B Srinivas
Juvenile myoclonic epilepsy (JME) is a common genetically determined idiopathic generalized epilepsy. JME typically presents with generalized tonic-clonic, myoclonic or absence seizures or a combinati...

Cortical localization of scalp electrodes on three-dimensional brain surface using frameless stereotactic image guidance system [2007] - 122KB
by D Kim, SW Kim, EY Joo, WS Tae, SJ Choi, SB Hong
Cortical localization of EEG signals provides critical information regarding evaluation and management of patients with partial epilepsy. This localization method require the knowledge of the precise ...

Continuity of surface negativity form fissural cortex to gyral cortex at latency of MEG spike peak [2007] - 130KB
by KA Salayev, N Nakasato, M Ishitobi, H Shamoto, A Kanno, K Iinuma, S Tsuchiya
Equivalent current dipole (ECD) model in magnetoencephalography (MEG) is a noninvasive method that is commonly used to estimate the source of the epileptogenic activity. However, the position of ECD i...

Neural connections among primary motor, primary sensory and supplementary motor areas: evaluated by cortico-cortical evoked potential [2007] - 110KB
by K Terada, N Usui, T Mihara, K Baba, K Matsuda, S Umeoka, K Usui, F Nakamura, Y Inoue
Functional mapping is important in epilepsy surgery. However, it is sometimes difficult to delineate eloquent areas by standard cortical stimulation. Matsumoto et al1 reported a new method (cortico-co...

New antiepileptic drug efficiency: A 5 year study in Hamilton, New Zealand [2007] - 226KB
by P Timmings, L Gilbertson
The availability of new anti-epileptic drugs (AEDs) promised improved seizure control and superior tolerability for patients with treatment resistant epilepsy. In New Zealand a unique situation arose,...

Genetic predictors of carbamazepine maintenance dose [2007] - 136KB
by M Makmor-Bakry, N Hitiris, E Butler, GJ Sills, MJ Brodie
Carbamazepine (CBZ) is the second most commonly prescribed antiepileptic drug in the UK. The dose of CBZ required to achieve optimal seizure control varies widely from patient to patient. Multiple hep...

Retrospective population pharmacokinetic analysis of levetiracetam in Western and Japanese adults [2007] - 119KB
by E Pigeolet, P Jacqmin, ML Sargentini-Maier, A Stockis
Levetiracetam (LEV), a second-generation antiepileptic drug (AED) indicated for the adjunctive treatment of partial-onset epilepsy, has been shown to possess a favourable pharmacokinetic profile. It i...

Chloral hydrate against benign convulsions with mild gastroenteritis [2007] - 113KB
by H Enoki
Benign convulsions with mild gastroenteritis are commonly seen in Japan and eastern Asia. They are characterized by afebrile generalized seizures associated with gastroenteritis in children aged from ...

Association analysis of a polymorphism of MDR1 Gene and refractory temporal lobe epilepsy in a Chinese population [2007] - 161KB
by Q Lu, L Wu, L Jin, Q Xu, Y Shen
Although pharmacoresistance is almost certainly due to several factors, the family of multidrug transporter proteins are likely to play a prominent role in this phenomenon given the often observed bro...

Design of GABA uptake inhibitors: synthesis and anticonvulsant properties [2007] - 120KB
by JV Ragavendran, PR Kumar, P Yogeswari
Epilepsy is the most common primary neurological disorder known, affecting 0.4-0.8% of the population and up to 50 million people worldwide. 4-aminobutyric acid (GABA), the major inhibitory neurotrans...