Authors
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Mohammad Rahmanian
Shahid beheshti university of medical sciences
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Shirin Yaghoobpoor
School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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Niloofar Deravi
Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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Mohadeseh Poudineh
School of Medicine, Zanjan University of Medical Sciences Zanjan, Iran .
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Seyedeh Nooshan Mirmohammadali
College of Health & Human Sciences, Kansas State University, Manhattan, KS 66502, USA
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Mohammad Ghasem Kashanizadeh
Azad University of Medical Sciences, Tehran, Iran.
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Amirhossein Poopak
5. Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
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Arezoo Faridzadeh
1. Department of Immunology and Allergy, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran 2. Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
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Gisou Erabi
Student research committee, Urmia university of medical sciences, Urmia ,Iran
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Erfan Amouei
Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology & Metabolism, Iran University of Medical Science, Tehran, Iran
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Masih Falahatian
Medical Radiation Sciences Research Group, Tabriz University of Medical Sciences, Tabriz, Iran
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Afshin Khani
Mazandaran University of Medical Sciences, Sari, Iran
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Sayedeh-Fatemeh Sadatmadani
. Medical Doctor, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
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Masoud Noroozi
Department of Biomedical Engineering, Tarbiat Modares University, Tehran, Iran
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Fatemeh Dehghani Firouzabadi
.Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Keywords:
NAFLD, diabetes Mellitus, neuropathy
Abstract
Nonalcoholic fatty liver disease (NAFLD) refers to the uncontrolled accumulation of triglyceride (TG) in the liver when the person has no other liver disease etiologies. Among all causes of neuropathy, diabetic neuropathy is the most common one worldwide, and it causes notable morbidity and increases mortality. The prevalence of diabetic neuropathy and NAFLD has been demonstrated in few studies. This study aims to summarize existing data estimating peripheral diabetic neuropathy prevalence among sonographically detected NAFLD patients. We searched PubMed, Scopus, Web of Science, and Google scholar for articles in the English language up until October 2021 for the clinical trials of diabetic neuropathy in NAFLD patients and used the articles for a systematic review and meta-analysis. Seven studies (6,918 patients with type 2 diabetes mellitus (T2DM)) were involved. The prevalence of diabetic neuropathy among T2DM patients with ultrasound (US) detected-NAFLD was 0.48 (95% CI= 0.31-0.65, I2= 99.01%), however it was not significantly different from patients without NAFLD (OR=1.02, 95% CI= 0.89-1.17. p=0.748, I2=81.6%). The prevalence of diabetic neuropathy among T2DM patients with NAFLD is not significantly different from patients without NAFLD.
