Association of platelet glycoprotein Ia C807T polymorphism with ischemic stroke risk in young and elderly populations in Uzbekistan: A case- control study

Abstract

Background: Ischemic stroke remains a significant health concern, with a growing incidence among younger populations. While traditional risk factors such as hypertension and smoking are well- documented, the genetic predisposition to stroke, particularly the role of GP Ia C807T polymorphism, is still debated. Given the limited genetic studies in Central Asia, investigating this polymorphism in Uzbekistan’s young stroke patients is essential. Objective: This study aims to determine whether the GP Ia C807T polymorphism is associated with an increased risk of ischemic stroke in young individuals in Uzbekistan.

Methods: A case-control study was conducted involving 90 ischemic stroke patients aged ≤50 years, 92 patients >50 years, and 168 healthy controls. Genomic DNA was extracted from venous blood samples, and genotyping was performed using PCR-RFLP analysis. Statistical comparisons were made using logistic regression, adjusting for confounding factors.

Results: Hypertension and smoking were identified as significant risk factors for ischemic stroke in both young and elderly patients (p<0.05). However, no statistically significant association was observed between the GP Ia C807T polymorphism and ischemic stroke in either group (p>0.05).

Conclusion: This study suggests that traditional risk factors, rather than genetic variations in GP Ia C807T, play a more prominent role in ischemic stroke development among young individuals in Uzbekistan. Further research incorporating larger cohorts and additional genetic markers is needed to clarify the genetic contribution to stroke susceptibility in this population.